Design and Synthesis of small-molecule stabilizers of protein-protein interactions (PPIs) as a novel class of therapeutic agents and basic research tool compounds
Development and implementation of HTS-applicable assays (HTRF, AlphaScreen, FP) for the identification of small-molecule PPI stabilizers from compound libraries.
Synthesis of small molecules and fragments that stabilize the 14-3-3 PPI within interactions with number of partner proteins (Tau, Gab2, NfkappaB, BAD, BAX, ASK1) that are known to be related to neurodegeneration, oncology, inflammation, metabolic diseases.